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CHOP: haplotype-aware path indexing in population graphs

The practical use of graph-based reference genomes depends on the ability to align reads to them. Performing substring queries to paths through these graphs lies at the core of this task. The combination of increasing pattern length and encoded variations inevitably leads to a combinatorial explosio...

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Détails bibliographiques
Publié dans:Genome Biol
Auteurs principaux: Mokveld, Tom, Linthorst, Jasper, Al-Ars, Zaid, Holstege, Henne, Reinders, Marcel
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066762/
https://ncbi.nlm.nih.gov/pubmed/32160922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-01963-y
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