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CHOP: haplotype-aware path indexing in population graphs

The practical use of graph-based reference genomes depends on the ability to align reads to them. Performing substring queries to paths through these graphs lies at the core of this task. The combination of increasing pattern length and encoded variations inevitably leads to a combinatorial explosio...

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Bibliografske podrobnosti
izdano v:Genome Biol
Main Authors: Mokveld, Tom, Linthorst, Jasper, Al-Ars, Zaid, Holstege, Henne, Reinders, Marcel
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066762/
https://ncbi.nlm.nih.gov/pubmed/32160922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-01963-y
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