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A haplotype-aware de novo assembly of related individuals using pedigree sequence graph

MOTIVATION: Reconstructing high-quality haplotype-resolved assemblies for related individuals has important applications in Mendelian diseases and population genomics. Through major genomics sequencing efforts such as the Personal Genome Project, the Vertebrate Genome Project (VGP) and the Genome in...

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Detalhes bibliográficos
Publicado no:Bioinformatics
Main Authors: Garg, Shilpa, Aach, John, Li, Heng, Sebenius, Isaac, Durbin, Richard, Church, George
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7759745/
https://ncbi.nlm.nih.gov/pubmed/31860070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btz942
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