Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells

WNT proteins are secreted symmetry breaking signals that interact with cell surface receptors of the FZD family to regulate a multitude of developmental processes. Studying selectivity between WNTs and FZDs has been hampered by the paucity of purified WNT proteins and by their apparent non-selective...

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Опубликовано в: :eLife
Главные авторы: Gumber, Diana, Do, Myan, Suresh Kumar, Neya, Sonavane, Pooja R, Wu, Christina C N, Cruz, Luisjesus S, Grainger, Stephanie, Carson, Dennis, Gaasterland, Terry, Willert, Karl
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2020
Предметы:
Developmental Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7759383/
https://ncbi.nlm.nih.gov/pubmed/33331818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.63060
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