Lataa...

Prodrugs of γ‐Alkyl‐Modified Nucleoside Triphosphates: Improved Inhibition of HIV Reverse Transcriptase

The development of nucleoside triphosphate prodrugs is one option to apply nucleoside reverse transcriptase inhibitors. Herein, we report the synthesis and evaluation of d4TTP analogues, in which the γ‐phosphate was modified covalently by lipophilic alkyl residues, and acyloxybenzyl prodrugs of thes...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Angew Chem Int Ed Engl
Päätekijät: Zhao, Chenglong, Weber, Stefan, Schols, Dominique, Balzarini, Jan, Meier, Chris
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756582/
https://ncbi.nlm.nih.gov/pubmed/32379948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202003073
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!