Prodrugs of γ‐Alkyl‐Modified Nucleoside Triphosphates: Improved Inhibition of HIV Reverse Transcriptase

The development of nucleoside triphosphate prodrugs is one option to apply nucleoside reverse transcriptase inhibitors. Herein, we report the synthesis and evaluation of d4TTP analogues, in which the γ‐phosphate was modified covalently by lipophilic alkyl residues, and acyloxybenzyl prodrugs of thes...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Zhao, Chenglong, Weber, Stefan, Schols, Dominique, Balzarini, Jan, Meier, Chris
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756582/
https://ncbi.nlm.nih.gov/pubmed/32379948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202003073
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