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Prodrugs of γ‐Alkyl‐Modified Nucleoside Triphosphates: Improved Inhibition of HIV Reverse Transcriptase

The development of nucleoside triphosphate prodrugs is one option to apply nucleoside reverse transcriptase inhibitors. Herein, we report the synthesis and evaluation of d4TTP analogues, in which the γ‐phosphate was modified covalently by lipophilic alkyl residues, and acyloxybenzyl prodrugs of thes...

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Bibliografiske detaljer
Udgivet i:Angew Chem Int Ed Engl
Main Authors: Zhao, Chenglong, Weber, Stefan, Schols, Dominique, Balzarini, Jan, Meier, Chris
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756582/
https://ncbi.nlm.nih.gov/pubmed/32379948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202003073
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