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Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV‐1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine

The retrovirus HIV‐1 has been a major health issue since its discovery in the early 80s. In 2017, over 37 million people were infected with HIV‐1, of which 1.8 million were new infections that year. Currently, the most successful treatment regimen is the highly active antiretroviral therapy (HAART),...

詳細記述

保存先:
書誌詳細
出版年:Protein Sci
主要な著者: Bertoletti, Nicole, Chan, Albert H., Schinazi, Raymond F., Yin, Y. Whitney, Anderson, Karen S.
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley & Sons, Inc. 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699100/
https://ncbi.nlm.nih.gov/pubmed/31301259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3681
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