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Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV‐1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine

The retrovirus HIV‐1 has been a major health issue since its discovery in the early 80s. In 2017, over 37 million people were infected with HIV‐1, of which 1.8 million were new infections that year. Currently, the most successful treatment regimen is the highly active antiretroviral therapy (HAART),...

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Dettagli Bibliografici
Pubblicato in:Protein Sci
Autori principali: Bertoletti, Nicole, Chan, Albert H., Schinazi, Raymond F., Yin, Y. Whitney, Anderson, Karen S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Inc. 2019
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699100/
https://ncbi.nlm.nih.gov/pubmed/31301259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3681
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