TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders

Genetic signal detection in genome‐wide association studies (GWAS) is enhanced by pooling small signals from multiple Single Nucleotide Polymorphism (SNP), for example, across genes and pathways. Because genes are believed to influence traits via gene expression, it is of interest to combine informa...

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Vydáno v:Am J Med Genet B Neuropsychiatr Genet
Hlavní autoři: Chatzinakos, Chris, Georgiadis, Foivos, Lee, Donghyung, Cai, Na, Vladimirov, Vladimir I., Docherty, Anna, Webb, Bradley T., Riley, Brien P., Flint, Jonathan, Kendler, Kenneth S., Daskalakis, Nikolaos P., Bacanu, Silviu‐Alin
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2020
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756231/
https://ncbi.nlm.nih.gov/pubmed/32954640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajmg.b.32823
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