A simple yet accurate correction for winner's curse can predict signals discovered in much larger genome scans

Motivation: For genetic studies, statistically significant variants explain far less trait variance than ‘sub-threshold’ association signals. To dimension follow-up studies, researchers need to accurately estimate ‘true’ effect sizes at each SNP, e.g. the true mean of odds ratios (ORs)/regression co...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Bioinformatics
Main Authors: Bigdeli, T. Bernard, Lee, Donghyung, Webb, Bradley Todd, Riley, Brien P., Vladimirov, Vladimir I., Fanous, Ayman H., Kendler, Kenneth S., Bacanu, Silviu-Alin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013908/
https://ncbi.nlm.nih.gov/pubmed/27187203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btw303
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados