Genetic ablation of Cullin-RING E3 ubiquitin ligase 7 restrains pressure overload-induced myocardial fibrosis

Fibrosis is a pathognomonic feature of structural heart disease and counteracted by distinct cardioprotective mechanisms, e.g. activation of the phosphoinositide 3-kinase (PI3K) / AKT pro-survival pathway. The Cullin-RING E3 ubiquitin ligase 7 (CRL7) was identified as negative regulator of PI3K/AKT...

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Veröffentlicht in:PLoS One
Hauptverfasser: Anger, Melanie, Scheufele, Florian, Ramanujam, Deepak, Meyer, Kathleen, Nakajima, Hidehiro, Field, Loren J., Engelhardt, Stefan, Sarikas, Antonio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755222/
https://ncbi.nlm.nih.gov/pubmed/33351822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0244096
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