Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen

Simian virus 40 (SV40) large tumor antigen (LT) triggers oncogenic transformation by inhibition of key tumor suppressor proteins, including p53 and members of the retinoblastoma family. In addition, SV40 transformation requires binding of LT to Cullin 7 (CUL7), a core component of Cullin-RING E3 ubi...

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Bibliographische Detailangaben
Hauptverfasser: Hartmann, Thomas, Xu, Xinsong, Kronast, Mira, Muehlich, Susanne, Meyer, Kathleen, Zimmermann, Wolfgang, Hurwitz, Jerard, Pan, Zhen-Qiang, Engelhardt, Stefan, Sarikas, Antonio
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948260/
https://ncbi.nlm.nih.gov/pubmed/24550499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401556111
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