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Impact of cytochrome P450 variation on meperidine N-demethylation to the neurotoxic metabolite normeperidine

1. Meperidine is an opioid analgesic that undergoes N-demethylation to form the neurotoxic metabolite normeperidine. Previous studies indicate that meperidine N-demethylation is catalyzed by cytochrome P450 2B6 (CYP2B6), CYP3A4, and CYP2C19. 2. The purpose of this study was to examine the relative P...

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Detalhes bibliográficos
Publicado no:Xenobiotica
Main Authors: Murray, Jessica L., Mercer, Susan L., Jackson, Klarissa D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755165/
https://ncbi.nlm.nih.gov/pubmed/30902024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2019.1599465
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