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Impact of cytochrome P450 variation on meperidine N-demethylation to the neurotoxic metabolite normeperidine
1. Meperidine is an opioid analgesic that undergoes N-demethylation to form the neurotoxic metabolite normeperidine. Previous studies indicate that meperidine N-demethylation is catalyzed by cytochrome P450 2B6 (CYP2B6), CYP3A4, and CYP2C19. 2. The purpose of this study was to examine the relative P...
Shranjeno v:
| izdano v: | Xenobiotica |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7755165/ https://ncbi.nlm.nih.gov/pubmed/30902024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2019.1599465 |
| Oznake: |
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