Rapid, point-of-care molecular diagnostics with Cas13

Rapid nucleic acid testing is a critical component of a robust infrastructure for increased disease surveillance. Here, we report a microfluidic platform for point-of-care, CRISPR-based molecular diagnostics. We first developed a nucleic acid test which pairs distinct mechanisms of DNA and RNA ampli...

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Vydáno v:medRxiv
Hlavní autoři: Agrawal, Shreeya, Fanton, Alison, Chandrasekaran, Sita S., Charrez, Bérénice, Escajeda, Arturo M., Son, Sungmin, Mcintosh, Roger, Bhuiya, Abdul, de León Derby, María Díaz, Switz, Neil A., Armstrong, Maxim, Harris, Andrew R., Prywes, Noam, Lukarska, Maria, Biering, Scott B., Smock, Dylan C. J., Mok, Amanda, Knott, Gavin J., Dang, Qi, Van Dis, Erik, Dugan, Eli, Kim, Shin, Liu, Tina Y., Harris, Eva, Stanley, Sarah A., Lareau, Liana F., Tan, Ming X., Fletcher, Daniel A., Doudna, Jennifer A., Savage, David F., Hsu, Patrick D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755151/
https://ncbi.nlm.nih.gov/pubmed/33354689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.12.14.20247874
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