Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells

During affinity maturation, germinal center (GC) B cells alternate between proliferation and somatic hypermutation in the dark zone (DZ) and affinity-dependent selection in the light zone (LZ). This anatomical segregation imposes that the vigorous proliferation that allows clonal expansion of positi...

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Detalles Bibliográficos
Publicado en:J Exp Med
Main Authors: Pae, Juhee, Ersching, Jonatan, Castro, Tiago B.R., Schips, Marta, Mesin, Luka, Allon, Samuel J., Ordovas-Montanes, Jose, Mlynarczyk, Coraline, Melnick, Ari, Efeyan, Alejo, Shalek, Alex K., Meyer-Hermann, Michael, Victora, Gabriel D.
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754672/
https://ncbi.nlm.nih.gov/pubmed/33332554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201699
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