HaloTag‐Targeted Sirtuin‐Rearranging Ligand (SirReal) for the Development of Proteolysis‐Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 (Sirt2)

We have discovered the sirtuin‐rearranging ligands (SirReals) as a novel class of highly potent and selective inhibitors of the NAD(+)‐dependent lysine deacetylase sirtuin 2 (Sirt2). In previous studies, conjugation of a SirReal with a ligand for the E3 ubiquitin ligase cereblon to form a so‐called...

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Publié dans:Chembiochem
Auteurs principaux: Schiedel, Matthias, Lehotzky, Attila, Szunyogh, Sandor, Oláh, Judit, Hammelmann, Sören, Wössner, Nathalie, Robaa, Dina, Einsle, Oliver, Sippl, Wolfgang, Ovádi, Judit, Jung, Manfred
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
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Full Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754454/
https://ncbi.nlm.nih.gov/pubmed/32672888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000351
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