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Experimental Carbonic Anhydrase Inhibitors for the Treatment of Hypoxic Tumors

Carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII are overexpressed in many hypoxic tumors as a consequence of the hypoxia inducible factor (HIF) activation cascade, being present in limited amounts in normal tissues. These enzymes together with many others are involved in the pH regulation an...

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Pubblicato in:J Exp Pharmacol
Autore principale: Supuran, Claudiu T
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7751321/
https://ncbi.nlm.nih.gov/pubmed/33364855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JEP.S265620
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