PEG Linker Length Strongly Affects Tumor Cell Killing by PEGylated Carbonic Anhydrase Inhibitors in Hypoxic Carcinomas Expressing Carbonic Anhydrase IX

Hypoxic tumors overexpress membrane-bound isozymes of carbonic anhydrase (CA) CA IX and CA XII, which play key roles in tumor pH homeostasis under hypoxia. Selective inhibition of these CA isozymes has the potential to generate pH imbalances that can lead to tumor cell death. Since these isozymes ar...

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Foilsithe in:Int J Mol Sci
Main Authors: Mondal, Utpal K., Doroba, Kate, Shabana, Ahmed M., Adelberg, Rachel, Alam, Md. Raqibul, Supuran, Claudiu T., Ilies, Marc A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2021
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7866101/
https://ncbi.nlm.nih.gov/pubmed/33498779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22031120
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