Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells

Tumor-associated macrophages (TAMs) can have protumor properties, including suppressing immune responses, promoting vascularization and, consequently, augmenting tumor progression. To stop TAM-mediated immunosuppression, we use a novel treatment by injecting antibodies specific for scavenger recepto...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Eisinger, Silke, Sarhan, Dhifaf, Boura, Vanessa F., Ibarlucea-Benitez, Itziar, Tyystjärvi, Sofia, Oliynyk, Ganna, Arsenian-Henriksson, Marie, Lane, David, Wikström, Stina L., Kiessling, Rolf, Virgilio, Tommaso, Gonzalez, Santiago F., Kaczynska, Dagmara, Kanatani, Shigeaki, Daskalaki, Evangelia, Wheelock, Craig E., Sedimbi, Saikiran, Chambers, Benedict J., Ravetch, Jeffrey V., Karlsson, Mikael C. I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7750482/
https://ncbi.nlm.nih.gov/pubmed/33229588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015343117
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