Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells

Tumor-associated macrophages (TAMs) can have protumor properties, including suppressing immune responses, promoting vascularization and, consequently, augmenting tumor progression. To stop TAM-mediated immunosuppression, we use a novel treatment by injecting antibodies specific for scavenger recepto...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Eisinger, Silke, Sarhan, Dhifaf, Boura, Vanessa F., Ibarlucea-Benitez, Itziar, Tyystjärvi, Sofia, Oliynyk, Ganna, Arsenian-Henriksson, Marie, Lane, David, Wikström, Stina L., Kiessling, Rolf, Virgilio, Tommaso, Gonzalez, Santiago F., Kaczynska, Dagmara, Kanatani, Shigeaki, Daskalaki, Evangelia, Wheelock, Craig E., Sedimbi, Saikiran, Chambers, Benedict J., Ravetch, Jeffrey V., Karlsson, Mikael C. I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
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Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7750482/
https://ncbi.nlm.nih.gov/pubmed/33229588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015343117
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