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Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity

Given the role of myeloid cells in T cell activation and in the antitumor response, targeting checkpoint molecules expressed on this population represents a promising strategy to augment antitumor immunity. However, myeloid checkpoints that can be effectively used as immunotherapy targets are still...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Ibarlucea-Benitez, Itziar, Weitzenfeld, Polina, Smith, Patrick, Ravetch, Jeffrey V.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256000/
https://ncbi.nlm.nih.gov/pubmed/34155121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2107424118
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