MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

The MYC genes are the most frequently activated oncogenes in human tumors and are hence attractive therapeutic targets. MYCN amplification leads to poor clinical outcome in childhood neuroblastoma, yet strategies to modulate the function of MYCN do not exist. Here we show that 10058-F4, a characteri...

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Detalhes bibliográficos
Main Authors: Zirath, Hanna, Frenzel, Anna, Oliynyk, Ganna, Segerström, Lova, Westermark, Ulrica K., Larsson, Karin, Munksgaard Persson, Matilda, Hultenby, Kjell, Lehtiö, Janne, Einvik, Christer, Påhlman, Sven, Kogner, Per, Jakobsson, Per-Johan, Arsenian Henriksson, Marie
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690852/
https://ncbi.nlm.nih.gov/pubmed/23733953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222404110
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