MYCN-enhanced Oxidative and Glycolytic Metabolism Reveals Vulnerabilities for Targeting Neuroblastoma

In pediatric neuroblastoma, MYCN-amplification correlates to poor clinical outcome and new treatment options are needed for these patients. Identifying the metabolic adaptations crucial for tumor progression may be a promising strategy to discover novel therapeutic targets. Here, we have combined pr...

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Publicado no:iScience
Main Authors: Oliynyk, Ganna, Ruiz-Pérez, María Victoria, Sainero-Alcolado, Lourdes, Dzieran, Johanna, Zirath, Hanna, Gallart-Ayala, Héctor, Wheelock, Craig E., Johansson, Henrik J., Nilsson, Roland, Lehtiö, Janne, Arsenian-Henriksson, Marie
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889365/
https://ncbi.nlm.nih.gov/pubmed/31670074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.10.020
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