MYCN-amplified neuroblastoma maintains an aggressive and undifferentiated phenotype by deregulation of estrogen and NGF signaling

Neuroblastoma (NB) is a remarkably heterogenic childhood tumor of the sympathetic nervous system with clinical behavior ranging from spontaneous regression to poorly differentiated tumors and metastasis. MYCN is amplified in 20% of cases and correlates with an undifferentiated, aggressive phenotype...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Dzieran, Johanna, Rodriguez Garcia, Aida, Westermark, Ulrica Kristina, Henley, Aine Brigette, Eyre Sánchez, Elena, Träger, Catarina, Johansson, Henrik Johan, Lehtiö, Janne, Arsenian-Henriksson, Marie
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2018
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819392/
https://ncbi.nlm.nih.gov/pubmed/29374092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710901115
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