MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

The MYC genes are the most frequently activated oncogenes in human tumors and are hence attractive therapeutic targets. MYCN amplification leads to poor clinical outcome in childhood neuroblastoma, yet strategies to modulate the function of MYCN do not exist. Here we show that 10058-F4, a characteri...

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Bibliografische gegevens
Hoofdauteurs: Zirath, Hanna, Frenzel, Anna, Oliynyk, Ganna, Segerström, Lova, Westermark, Ulrica K., Larsson, Karin, Munksgaard Persson, Matilda, Hultenby, Kjell, Lehtiö, Janne, Einvik, Christer, Påhlman, Sven, Kogner, Per, Jakobsson, Per-Johan, Arsenian Henriksson, Marie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2013
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690852/
https://ncbi.nlm.nih.gov/pubmed/23733953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222404110
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