Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells

Tumor-associated macrophages (TAMs) can have protumor properties, including suppressing immune responses, promoting vascularization and, consequently, augmenting tumor progression. To stop TAM-mediated immunosuppression, we use a novel treatment by injecting antibodies specific for scavenger recepto...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Eisinger, Silke, Sarhan, Dhifaf, Boura, Vanessa F., Ibarlucea-Benitez, Itziar, Tyystjärvi, Sofia, Oliynyk, Ganna, Arsenian-Henriksson, Marie, Lane, David, Wikström, Stina L., Kiessling, Rolf, Virgilio, Tommaso, Gonzalez, Santiago F., Kaczynska, Dagmara, Kanatani, Shigeaki, Daskalaki, Evangelia, Wheelock, Craig E., Sedimbi, Saikiran, Chambers, Benedict J., Ravetch, Jeffrey V., Karlsson, Mikael C. I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7750482/
https://ncbi.nlm.nih.gov/pubmed/33229588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015343117
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