Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells

Tumor-associated macrophages (TAMs) can have protumor properties, including suppressing immune responses, promoting vascularization and, consequently, augmenting tumor progression. To stop TAM-mediated immunosuppression, we use a novel treatment by injecting antibodies specific for scavenger recepto...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Eisinger, Silke, Sarhan, Dhifaf, Boura, Vanessa F., Ibarlucea-Benitez, Itziar, Tyystjärvi, Sofia, Oliynyk, Ganna, Arsenian-Henriksson, Marie, Lane, David, Wikström, Stina L., Kiessling, Rolf, Virgilio, Tommaso, Gonzalez, Santiago F., Kaczynska, Dagmara, Kanatani, Shigeaki, Daskalaki, Evangelia, Wheelock, Craig E., Sedimbi, Saikiran, Chambers, Benedict J., Ravetch, Jeffrey V., Karlsson, Mikael C. I.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7750482/
https://ncbi.nlm.nih.gov/pubmed/33229588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015343117
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