Safety and nonclinical and clinical pharmacokinetics of PC945, a novel inhaled triazole antifungal agent

PC945 is a novel antifungal triazole formulated for nebulized delivery to treat lung Aspergillus infections. Pharmacokinetic and safety profiles from nonclinical studies and clinical trials in healthy subjects, and subjects with mild asthma were characterized. Toxicokinetics were assessed following...

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Publicado en:Pharmacol Res Perspect
Autores principales: Cass, Lindsey, Murray, Alison, Davis, Amanda, Woodward, Kathy, Albayaty, Muna, Ito, Kazuhiro, Strong, Pete, Ayrton, John, Brindley, Charlie, Prosser, Jayne, Murray, John, French, Eddie, Haywood, Phillip, Wallis, Christopher, Rapeport, Garth
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749516/
https://ncbi.nlm.nih.gov/pubmed/33340279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.690
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