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Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist
Chirality is an important consideration in drug development: it can influence recognition of the intended target, pharmacokinetics, and off-target effects. Here, we investigate how chirality affects the activity and mechanism of action of RJW100, a racemic agonist of the nuclear receptors liver rece...
Shranjeno v:
| izdano v: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7747700/ https://ncbi.nlm.nih.gov/pubmed/33335203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79251-9 |
| Oznake: |
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