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Upregulation of 5′-terminal oligopyrimidine mRNA translation upon loss of the ARF tumor suppressor

Tumor cells require nominal increases in protein synthesis in order to maintain high proliferation rates. As such, tumor cells must acquire enhanced ribosome production. How the numerous mutations in tumor cells ultimately achieve this aberrant production is largely unknown. The gene encoding ARF is...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Cottrell, Kyle A., Chiou, Ryan C., Weber, Jason D.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7747592/
https://ncbi.nlm.nih.gov/pubmed/33335292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79379-8
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