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Hypergrowth mTORC1 Signals Translationally Activate the ARF Tumor Suppressor Checkpoint
The ARF tumor suppressor is a potent sensor of hyperproliferative cues emanating from oncogenic signaling. ARF responds to these cues by eliciting a cell cycle arrest, effectively abating the tumorigenic potential of these stimuli. Prior reports have demonstrated that oncogenic Ras(V12) signaling in...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3255786/ https://ncbi.nlm.nih.gov/pubmed/22064482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06030-11 |
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