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The ARF tumor suppressor controls Drosha translation to prevent Ras-driven transformation
ARF is a multifunctional tumor suppressor that acts as both a sensor of oncogenic stimuli and as a key regulator of ribosome biogenesis. Recently, our group established the DEAD-box RNA helicase and microRNA (miRNA) microprocessor accessory subunit, DDX5, as a critical target of basal ARF function....
Tallennettuna:
| Päätekijät: | , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2013
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3934099/ https://ncbi.nlm.nih.gov/pubmed/23318441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.601 |
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