Germinal Center B-Cells Resist Transformation by Kras Independently of Tumor Suppressor Arf

Activating mutations in Ras (N- and K-) are the most common point mutations found in patients with multiple myeloma (MM) and are associated with poor clinical outcome. We sought to directly examine the role of Ras activation in MM pathogenesis and used two different tissue-specific Cre recombinase m...

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Detalhes bibliográficos
Main Authors: Mullins, Chelsea D., Su, Mack Y., Hucthagowder, Vishwanathan, Chu, Liang, Lu, Lan, Kulkarni, Shashikant, Novack, Deborah, Vij, Ravi, Tomasson, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3692489/
https://ncbi.nlm.nih.gov/pubmed/23825691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067941
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