Bothrops moojeni L-amino acid oxidase induces apoptosis and epigenetic modulation on Bcr-Abl(+) cells

BACKGROUND: Resistance to apoptosis in chronic myeloid leukemia (CML) is associated with constitutive tyrosine kinase activity of the Bcr-Abl oncoprotein. The deregulated expression of apoptosis-related genes and alteration in epigenetic machinery may also contribute to apoptosis resistance in CML....

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Venom Anim Toxins Incl Trop Dis
Egile Nagusiak: Burin, Sandra Mara, Cacemiro, Maira da Costa, Cominal, Juçara Gastaldi, Grandis, Rone Aparecido De, Machado, Ana Rita Thomazela, Donaires, Flavia Sacilotto, Cintra, Adelia Cristina Oliveira, Ambrosio, Luciana, Antunes, Lusânia Maria Greggi, Sampaio, Suely Vilela, de Castro, Fabíola Attié
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Centro de Estudos de Venenos e Animais Peçonhentos 2020
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7737401/
https://ncbi.nlm.nih.gov/pubmed/33354202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/1678-9199-JVATITD-2020-0123
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