Bothrops moojeni L-amino acid oxidase induces apoptosis and epigenetic modulation on Bcr-Abl(+) cells

BACKGROUND: Resistance to apoptosis in chronic myeloid leukemia (CML) is associated with constitutive tyrosine kinase activity of the Bcr-Abl oncoprotein. The deregulated expression of apoptosis-related genes and alteration in epigenetic machinery may also contribute to apoptosis resistance in CML....

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Dades bibliogràfiques
Publicat a:J Venom Anim Toxins Incl Trop Dis
Autors principals: Burin, Sandra Mara, Cacemiro, Maira da Costa, Cominal, Juçara Gastaldi, Grandis, Rone Aparecido De, Machado, Ana Rita Thomazela, Donaires, Flavia Sacilotto, Cintra, Adelia Cristina Oliveira, Ambrosio, Luciana, Antunes, Lusânia Maria Greggi, Sampaio, Suely Vilela, de Castro, Fabíola Attié
Format: Artigo
Idioma:Inglês
Publicat: Centro de Estudos de Venenos e Animais Peçonhentos 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7737401/
https://ncbi.nlm.nih.gov/pubmed/33354202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/1678-9199-JVATITD-2020-0123
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