Cytotoxic and pro-apoptotic action of MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, towards leukemic cells

BACKGROUND: Chronic myeloid leukemia (CML) is a BCR-ABL1(+) myeloproliferative neoplasm marked by increased myeloproliferation and presence of leukemic cells resistant to apoptosis. The current first-line therapy for CML is administration of the tyrosine kinase inhibitors imatinib mesylate, dasatini...

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Bibliographische Detailangaben
Veröffentlicht in:J Venom Anim Toxins Incl Trop Dis
Hauptverfasser: Benati, Rogério Bodini, Costa, Tássia Rafaela, Cacemiro, Maira da Costa, Sampaio, Suely Vilela, de Castro, Fabíola Attié, Burin, Sandra Mara
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300906/
https://ncbi.nlm.nih.gov/pubmed/30598659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40409-018-0180-9
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