Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism

Local myonecrosis is the main event resulting from snakebite envenomation by the Bothrops genus and, frequently, it is not efficiently neutralized by antivenom administration. Proteases, phospholipases A(2) (PLA(2)) and PLA(2)-like toxins are found in venom related to muscle damage. Functional sites...

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Publicado en:Sci Rep
Main Authors: Salvador, Guilherme H. M., Dreyer, Thiago R., Gomes, Antoniel A. S., Cavalcante, Walter L. G., dos Santos, Juliana I., Gandin, César A., de Oliveira Neto, Mário, Gallacci, Márcia, Fontes, Marcos R. M.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037679/
https://ncbi.nlm.nih.gov/pubmed/29985425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28584-7
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