Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism

Local myonecrosis is the main event resulting from snakebite envenomation by the Bothrops genus and, frequently, it is not efficiently neutralized by antivenom administration. Proteases, phospholipases A(2) (PLA(2)) and PLA(2)-like toxins are found in venom related to muscle damage. Functional sites...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Salvador, Guilherme H. M., Dreyer, Thiago R., Gomes, Antoniel A. S., Cavalcante, Walter L. G., dos Santos, Juliana I., Gandin, César A., de Oliveira Neto, Mário, Gallacci, Márcia, Fontes, Marcos R. M.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037679/
https://ncbi.nlm.nih.gov/pubmed/29985425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28584-7
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