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KCa channel activation normalizes endothelial function in Type 2 Diabetic resistance arteries by improving intracellular Ca(2+) mobilization
BACKGROUND: Endothelial dysfunction is an early pathogenic event in the progression of cardiovascular disease in patients with type 2 diabetes (T2D). Endothelial KCa2.3 and KCa3.1 K(+) channels are important regulators of arterial diameter, and we thus hypothesized that SKA-31, a small molecule acti...
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| Gepubliceerd in: | Metabolism |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7736096/ https://ncbi.nlm.nih.gov/pubmed/33039407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2020.154390 |
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