KCa channel activation normalizes endothelial function in Type 2 Diabetic resistance arteries by improving intracellular Ca(2+) mobilization

BACKGROUND: Endothelial dysfunction is an early pathogenic event in the progression of cardiovascular disease in patients with type 2 diabetes (T2D). Endothelial KCa2.3 and KCa3.1 K(+) channels are important regulators of arterial diameter, and we thus hypothesized that SKA-31, a small molecule acti...

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Publicado no:Metabolism
Main Authors: Mishra, Ramesh C, Kyle, Barry D, Kendrick, Dylan J, Svystonyuk, Daniyil, Kieser, Teresa, Fedak, Paul WM, Wulff, Heike, Braun, Andrew P
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736096/
https://ncbi.nlm.nih.gov/pubmed/33039407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2020.154390
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