Structural basis of TRPC4 regulation by calmodulin and pharmacological agents

Canonical transient receptor potential channels (TRPC) are involved in receptor-operated and/or store-operated Ca(2+) signaling. Inhibition of TRPCs by small molecules was shown to be promising in treating renal diseases. In cells, the channels are regulated by calmodulin (CaM). Molecular details of...

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Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Vinayagam, Deivanayagabarathy, Quentin, Dennis, Yu-Strzelczyk, Jing, Sitsel, Oleg, Merino, Felipe, Stabrin, Markus, Hofnagel, Oliver, Yu, Maolin, Ledeboer, Mark W, Nagel, Georg, Malojcic, Goran, Raunser, Stefan
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2020
Soggetti:
Structural Biology and Molecular Biophysics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7735759/
https://ncbi.nlm.nih.gov/pubmed/33236980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60603
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