Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model

[Image: see text] The nonselective Ca(2+)-permeable transient receptor potential (TRP) channels play important roles in diverse cellular processes, including actin remodeling and cell migration. TRP channel subfamily C, member 5 (TRPC5) helps regulate a tight balance of cytoskeletal dynamics in podo...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Yu, Maolin, Ledeboer, Mark W., Daniels, Matthew, Malojcic, Goran, Tibbitts, Thomas T., Coeffet-Le Gal, Marie, Pan-Zhou, Xin-Ru, Westerling-Bui, Amy, Beconi, Maria, Reilly, John F., Mundel, Peter, Harmange, Jean-Christophe
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862342/
https://ncbi.nlm.nih.gov/pubmed/31749913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00430
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