The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanism

VPS34 complex II (VPS34CII) is a 386-kDa assembly of the lipid kinase subunit VPS34 and three regulatory subunits that altogether function as a prototypical class III phosphatidylinositol-3-kinase (PI3K). When the active VPS34CII complex is docked to the cytoplasmic surface of endosomal membranes, i...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Buckles, Thomas C., Ohashi, Yohei, Tremel, Shirley, McLaughlin, Stephen H., Pardon, Els, Steyaert, Jan, Gordon, Moshe T., Williams, Roger L., Falke, Joseph J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7732812/
https://ncbi.nlm.nih.gov/pubmed/33137306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.10.028
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