The VPS34 PI3K negatively regulates RAB-5 during endosome maturation

The GTPase Rab5 and phosphatidylinositol-3 phosphate [PI(3)P] coordinately regulate endosome trafficking. Rab5 recruits Vps34, the class III phosphoinositide 3-kinase (PI3K), to generate PI(3)P and recruit PI(3)P-binding proteins. Loss of Rab5 and loss of Vps34 have opposite effects on endosome size...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Law, Fiona, Seo, Jung Hwa, Wang, Ziqing, DeLeon, Jennifer L., Bolis, Yousstina, Brown, Ashley, Zong, Wei-Xing, Du, Guangwei, Rocheleau, Christian E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482978/
https://ncbi.nlm.nih.gov/pubmed/28455411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.194746
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