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Vps34 and the Armus/TBC-2 Rab GAPs: Putting the brakes on the endosomal Rab5 and Rab7 GTPases

Rab5 and Rab7 GTPases are key regulators of endosome maturation and lysosome fusion. They activate the class III phosphoinositide 3-kinase (PI3K) Vps34 to generate pools of phosphatidylinositol-3 phosphate [PI(3)P] on endosomes. Together PI(3)P and the GTP-bound Rabs coordinate the recruitment of en...

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Publicat a:Cell Logist
Autors principals: Law, Fiona, Rocheleau, Christian E.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739090/
https://ncbi.nlm.nih.gov/pubmed/29296513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21592799.2017.1403530
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