Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes

The lipid phosphatidylinositol-3-phosphate (PI3P) is a regulator of two fundamental but distinct cellular processes, endocytosis and autophagy, so its generation needs to be under precise temporal and spatial control. PI3P is generated by two complexes that both contain the lipid kinase VPS34: compl...

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Udgivet i:Nat Commun
Main Authors: Tremel, Shirley, Ohashi, Yohei, Morado, Dustin R., Bertram, Jessie, Perisic, Olga, Brandt, Laura T. L., von Wrisberg, Marie-Kristin, Chen, Zhuo A., Maslen, Sarah L., Kovtun, Oleksiy, Skehel, Mark, Rappsilber, Juri, Lang, Kathrin, Munro, Sean, Briggs, John A. G., Williams, Roger L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946940/
https://ncbi.nlm.nih.gov/pubmed/33692360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21695-2
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