Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

Phosphatidylinositol 3-kinase Vps34 complexes regulate intracellular membrane trafficking in endocytic sorting, cytokinesis and autophagy. We present the 4.4 Å crystal structure of the 385 kDa endosomal complex II (PIK3C3-CII), consisting of Vps34, Vps15 (p150), Vps30/Atg6 (Beclin 1) and Vps38 (UVRA...

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Bibliografiske detaljer
Udgivet i:Science
Main Authors: Rostislavleva, Ksenia, Soler, Nicolas, Ohashi, Yohei, Zhang, Lufei, Pardon, Els, Burke, John E., Masson, Glenn R., Johnson, Chris, Steyaert, Jan, Ktistakis, Nicholas T., Williams, Roger L.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601532/
https://ncbi.nlm.nih.gov/pubmed/26450213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac7365
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