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Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes
Phosphatidylinositol 3-kinase Vps34 complexes regulate intracellular membrane trafficking in endocytic sorting, cytokinesis and autophagy. We present the 4.4 Å crystal structure of the 385 kDa endosomal complex II (PIK3C3-CII), consisting of Vps34, Vps15 (p150), Vps30/Atg6 (Beclin 1) and Vps38 (UVRA...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4601532/ https://ncbi.nlm.nih.gov/pubmed/26450213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac7365 |
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