Blockage of AEP attenuates TBI-induced tau hyperphosphorylation and cognitive impairments in rats

Traumatic brain injury (TBI) is regarded as a high-risk factor for Alzheimer's disease (AD). Asparaginyl endopeptidase (AEP), a lysosomal cysteine protease involved in AD pathogenesis, is normally activated under acidic conditions and also in TBI. However, both the molecular mechanism underlyin...

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Detalles Bibliográficos
Publicado en:Aging (Albany NY)
Autores principales: Liu, Yi, Guo, Cuiping, Ding, Yi, Long, Xiaobing, Li, Wensheng, Ke, Dan, Wang, Qun, Liu, Rong, Wang, Jian-Zhi, Zhang, Huaqiu, Wang, Xiaochuan
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7732271/
https://ncbi.nlm.nih.gov/pubmed/33040048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103841
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