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Novel influenza polymerase PB2 inhibitors for the treatment of influenza A infection
Exploration of the chemical space of known influenza polymerase PB2 inhibitor Pimodivir, was performed by our group. We synthesized and identified compounds 16a and 16b, two novel thienopyrimidine derivatives displaying anti-influenza A activity in the single digit nanomolar range in cell culture. B...
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| Publicado en: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7732027/ https://ncbi.nlm.nih.gov/pubmed/31493987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126639 |
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