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Novel influenza polymerase PB2 inhibitors for the treatment of influenza A infection
Exploration of the chemical space of known influenza polymerase PB2 inhibitor Pimodivir, was performed by our group. We synthesized and identified compounds 16a and 16b, two novel thienopyrimidine derivatives displaying anti-influenza A activity in the single digit nanomolar range in cell culture. B...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7732027/ https://ncbi.nlm.nih.gov/pubmed/31493987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126639 |
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