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Selective Binding of Cyclodextrins with Leflunomide and Its Pharmacologically Active Metabolite Teriflunomide

The selectivity of encapsulation of leflunomide and teriflunomide by native α-, β- and γ-cyclodextrins was investigated through (1)H NMR and molecular modeling. Thermodynamic analysis revealed the main driving forces involved in the binding. For α-cyclodextrin, the partial encapsulation was obtained...

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Bibliografski detalji
Izdano u:Int J Mol Sci
Glavni autori: Terekhova, Irina, Kritskiy, Iliya, Agafonov, Mikhail, Kumeev, Roman, Martínez-Cortés, Carlos, Pérez-Sánchez, Horacio
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7730839/
https://ncbi.nlm.nih.gov/pubmed/33265979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21239102
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